Voxel-Based Lesion Symptom Mapping of Coarse Coding and Suppression Deficits in Patients With Right Hemisphere Damage Purpose This study examined right hemisphere (RH) neuroanatomical correlates of lexical–semantic deficits that predict narrative comprehension in adults with RH brain damage. Coarse semantic coding and suppression deficits were related to lesions by voxel-based lesion symptom mapping. Method Participants were 20 adults with RH cerebrovascular accidents. Measures of ... Supplement Article
Supplement Article  |   November 01, 2015
Voxel-Based Lesion Symptom Mapping of Coarse Coding and Suppression Deficits in Patients With Right Hemisphere Damage
 
Author Affiliations & Notes
  • Ying Yang
    Carnegie Mellon University, Pittsburgh, PA
  • Connie A. Tompkins
    University of Pittsburgh, PA
    Center for the Neural Basis of Cognition, University of Pittsburgh and Carnegie Mellon University, PA
  • Kimberly M. Meigh
    West Virginia University, Morgantown
  • Chantel S. Prat
    University of Washington, Seattle
  • Disclosure: The authors have declared that no competing interests existed at the time of publication.
    Disclosure: The authors have declared that no competing interests existed at the time of publication. ×
  • Correspondence to Ying Yang: yingy1@andrew.cmu.edu
  • Editor: Anastasia Raymer
    Editor: Anastasia Raymer×
  • Associate Editor: Sharon Antonucci
    Associate Editor: Sharon Antonucci×
Article Information
Special Populations / Normal Language Processing / Attention, Memory & Executive Functions / Traumatic Brain Injury / Supplement: Select Papers From the 44th Clinical Aphasiology Conference
Supplement Article   |   November 01, 2015
Voxel-Based Lesion Symptom Mapping of Coarse Coding and Suppression Deficits in Patients With Right Hemisphere Damage
American Journal of Speech-Language Pathology, November 2015, Vol. 24, S939-S952. doi:10.1044/2015_AJSLP-14-0149
History: Received September 15, 2014 , Revised March 10, 2015 , Accepted May 23, 2015
 
American Journal of Speech-Language Pathology, November 2015, Vol. 24, S939-S952. doi:10.1044/2015_AJSLP-14-0149
History: Received September 15, 2014; Revised March 10, 2015; Accepted May 23, 2015

Purpose This study examined right hemisphere (RH) neuroanatomical correlates of lexical–semantic deficits that predict narrative comprehension in adults with RH brain damage. Coarse semantic coding and suppression deficits were related to lesions by voxel-based lesion symptom mapping.

Method Participants were 20 adults with RH cerebrovascular accidents. Measures of coarse coding and suppression deficits were computed from lexical decision reaction times at short (175 ms) and long (1000 ms) prime-target intervals. Lesions were drawn on magnetic resonance imaging images and through normalization were registered on an age-matched brain template. Voxel-based lesion symptom mapping analysis was applied to build a general linear model at each voxel. Z score maps were generated for each deficit, and results were interpreted using automated anatomical labeling procedures.

Results A deficit in coarse semantic activation was associated with lesions to the RH posterior middle temporal gyrus, dorsolateral prefrontal cortex, and lenticular nuclei. A maintenance deficit for coarsely coded representations involved the RH temporal pole and dorsolateral prefrontal cortex more medially. Ineffective suppression implicated lesions to the RH inferior frontal gyrus and subcortical regions, as hypothesized, along with the rostral temporal pole.

Conclusion Beyond their scientific implications, these lesion–deficit correspondences may help inform the clinical diagnosis and enhance decisions about candidacy for deficit-focused treatment to improve narrative comprehension in individuals with RH damage.

Acknowledgments
This work was supported in part by National Institute on Deafness and Other Communication Disorders Grants DC01820, awarded to the second author, and DC009634, awarded to the fourth author. We are deeply indebted to Dan Kimberg for consulting on methods for scan preprocessing and analysis, Maxim Hammer for validation of the lesion drawings, Andrea Stocco for help with localizing the voxel-based lesion symptom mapping results, and our patients for their generosity of time and spirit.
Order a Subscription
Pay Per View
Entire American Journal of Speech-Language Pathology content & archive
24-hour access
This Article
24-hour access