The Time-Course of Lexical Activation During Sentence Comprehension in People With Aphasia Purpose To investigate the time-course of processing of lexical items in auditorily presented canonical (subject–verb–object) constructions in young, neurologically unimpaired control participants and participants with left-hemisphere damage and agrammatic aphasia. Method A cross modal picture priming (CMPP) paradigm was used to test 114 control participants and 8 participants ... Supplement Article
Supplement Article  |   May 01, 2012
The Time-Course of Lexical Activation During Sentence Comprehension in People With Aphasia
 
Author Affiliations & Notes
  • Michelle Ferrill
    San Diego State University, CA
    University of California, San Diego
  • Tracy Love
    San Diego State University, CA
    University of California, San Diego
  • Matthew Walenski
    San Diego State University, CA
    University of California, San Diego
  • Lewis P. Shapiro
    San Diego State University, CA
  • Correspondence to Tracy Love: tlove@mail.sdsu.edu
  • Editor: Swathi Kiran
    Editor: Swathi Kiran×
  • Associate Editor: Elizabeth Rochon
    Associate Editor: Elizabeth Rochon×
Article Information
Language Disorders / Aphasia / Supplement: Select Papers From the 41st Clinical Aphasiology Conference
Supplement Article   |   May 01, 2012
The Time-Course of Lexical Activation During Sentence Comprehension in People With Aphasia
American Journal of Speech-Language Pathology, May 2012, Vol. 21, S179-S189. doi:10.1044/1058-0360(2012/11-0109)
History: Received August 16, 2011 , Revised November 30, 2011 , Accepted February 3, 2012
 
American Journal of Speech-Language Pathology, May 2012, Vol. 21, S179-S189. doi:10.1044/1058-0360(2012/11-0109)
History: Received August 16, 2011; Revised November 30, 2011; Accepted February 3, 2012
Web of Science® Times Cited: 4

Purpose To investigate the time-course of processing of lexical items in auditorily presented canonical (subject–verb–object) constructions in young, neurologically unimpaired control participants and participants with left-hemisphere damage and agrammatic aphasia.

Method A cross modal picture priming (CMPP) paradigm was used to test 114 control participants and 8 participants with agrammatic aphasia for priming of a lexical item (direct object noun) immediately after it is initially encountered in the ongoing auditory stream and at 3 additional time points at 400-ms intervals.

Results The control participants demonstrated immediate activation of the lexical item, followed by a rapid loss (decay). The participants with aphasia demonstrated delayed activation of the lexical item.

Conclusion This evidence supports the hypothesis of a delay in lexical activation in people with agrammatic aphasia. The delay in lexical activation feeds syntactic processing too slowly, contributing to comprehension deficits in people with agrammatic aphasia.

Acknowledgments
The work reported in this paper was supported by National Institute on Deafness and Other Communication Disorders Grants DC009272 and DC000494, as well as T32DC007361; we thank the National Institutes of Health for their continuing support. We also thank our research assistants and our participants and their families for their time.
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