Behavioral and Pharmacological Treatment of Lexical-Semantic Deficits in a Single Patient With Primary Progressive Aphasia In the context of a hybrid multiple-baseline design, this study demonstrated the positive effects of a behavioral + pharmacological (dextroamphetamine) treatment for lexical-semantic deficits in an individual with primary progressive aphasia (PPA). Behavioral treatment entailed application of a cuing hierarchy to predicative adjectives in order to facilitate lexical retrieval. Treatment ... Supplement Article
Supplement Article  |   November 01, 1995
Behavioral and Pharmacological Treatment of Lexical-Semantic Deficits in a Single Patient With Primary Progressive Aphasia
 
Author Affiliations & Notes
  • Malcolm R. McNeil
    University of Pittsburgh, PA
  • Steven L. Small
    University of Pittsburgh, PA
  • Robert J. Masterson
    University of Pittsburgh, PA
  • Tepanta R. D. Fossett
    University of Pittsburgh, PA
  • Contact author: Malcolm R. McNeil, PhD, Communication Science and Disorders, University of Pittsburgh, 3347 Forbes Avenue, Pittsburgh, PA 15260.
Article Information
Special Populations / Older Adults & Aging / Language Disorders / Aphasia / Supplement: Clinical Aphasiology Conference Supplement
Supplement Article   |   November 01, 1995
Behavioral and Pharmacological Treatment of Lexical-Semantic Deficits in a Single Patient With Primary Progressive Aphasia
American Journal of Speech-Language Pathology, November 1995, Vol. 4, 76-87. doi:10.1044/1058-0360.0404.76
 
American Journal of Speech-Language Pathology, November 1995, Vol. 4, 76-87. doi:10.1044/1058-0360.0404.76

In the context of a hybrid multiple-baseline design, this study demonstrated the positive effects of a behavioral + pharmacological (dextroamphetamine) treatment for lexical-semantic deficits in an individual with primary progressive aphasia (PPA). Behavioral treatment entailed application of a cuing hierarchy to predicative adjectives in order to facilitate lexical retrieval. Treatment was effective for both antonym and synonym adjectives, although extended practice was required to achieve criterion. Generalization to nontreated adjectives, verbs, and prepositions was observed, and maintenance was difficult to disambiguate from the progressive nature of the disease. It was proposed that the mechanisms of activation and inhibition were responsible for improved performance. Differential effects between behavioral and behavioral + pharmacological treatment were not observed.

Acknowledgments
The authors acknowledge the extensive suggestions by reviewers Patrick Doyle and Linda Nicholas. Appreciation is also gratefully acknowledged for the extensive help of Thomas F. Campbell, Joseph R. Duffy, and Sheila R. Pratt.
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