Stuttering Treatment Research 1970–2005: II. Systematic Review Incorporating Trial Quality Assessment of Pharmacological Approaches PurposeTo complete a systematic review, incorporating trial quality assessment, of published research about pharmacological treatments for stuttering. Goals included the identification of treatment recommendations and research needs based on the available high-quality evidence.MethodMultiple readers reviewed 31 articles published between 1970 and 2005, using a written data extraction instrument developed as ... Tutorial
Tutorial  |   November 2006
Stuttering Treatment Research 1970–2005: II. Systematic Review Incorporating Trial Quality Assessment of Pharmacological Approaches
 
Author Affiliations & Notes
  • Anne K. Bothe
    The University of Georgia, Athens
  • Jason H. Davidow
    The University of Georgia, Athens
  • Robin E. Bramlett
    The University of Georgia, Athens
  • Duska M. Franic
    The University of Georgia, Athens
  • Roger J. Ingham
    University of California, Santa Barbara
  • Contact author: Anne K. Bothe, Department of Communication Sciences and Special Education, 556 Aderhold Hall, The University of Georgia, Athens, GA 30602. E-mail: abothe@uga.edu.
  • © 2006 American Speech-Language-Hearing Association
Article Information
Speech, Voice & Prosodic Disorders / Fluency Disorders / Tutorial
Tutorial   |   November 2006
Stuttering Treatment Research 1970–2005: II. Systematic Review Incorporating Trial Quality Assessment of Pharmacological Approaches
American Journal of Speech-Language Pathology, November 2006, Vol. 15, 342-352. doi:10.1044/1058-0360(2006/032)
History: Received October 19, 2005 , Revised March 28, 2006 , Accepted May 25, 2006
 
American Journal of Speech-Language Pathology, November 2006, Vol. 15, 342-352. doi:10.1044/1058-0360(2006/032)
History: Received October 19, 2005; Revised March 28, 2006; Accepted May 25, 2006
Web of Science® Times Cited: 29

PurposeTo complete a systematic review, incorporating trial quality assessment, of published research about pharmacological treatments for stuttering. Goals included the identification of treatment recommendations and research needs based on the available high-quality evidence.

MethodMultiple readers reviewed 31 articles published between 1970 and 2005, using a written data extraction instrument developed as a synthesis of existing standards and recommendations. Articles were then assessed using 5 methodological criteria and 4 outcomes criteria, also developed from previously published recommendations.

ResultsNone of the 31 articles met more than 3 of the 5 methodological criteria (M = 1.74). Four articles provided data to support a claim of short-term improvement in social, emotional, or cognitive variables. One article provided data to show that stuttering frequency was reduced to less than 5%, and 4 additional articles provided data to show that stuttering may have been reduced by at least half. Among the articles that met the trial quality inclusion criterion for the second stage of this review, none provided uncomplicated positive reports.

ConclusionsNone of the pharmacological agents tested for stuttering have been shown in methodologically sound reports to improve stuttering frequency to below 5%, to reduce stuttering by at least half, or to improve relevant social, emotional, or cognitive variables. These findings raise questions about the logic supporting the continued use of current pharmacological agents for stuttering.

Acknowledgments
This project was supported in part by Research Grant R01-004638 awarded to The University of Georgia on behalf of the first author by the National Institutes of Health. Our thanks to research assistants Brad Crowe, Sarah Harris, Ricque van Gerpen, Erin Weddle, and Lauren Yates. Only those articles specifically cited are provided in the reference list; the entire list of 31 articles reviewed is available upon request from the authors.
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